In their following work 54 they identified different types of capsule dynamics such as tank-treading, swinging, and tumbling. 20,50–58 Using two-dimensional numerical simulations, Shin and Sung 51 showed that the final equilibrium position for a given value of capsule elasticity varies with the Reynolds number. 46–49 Only recently, inertial microfluidics of deformable cells has caught attention. ![]() The dynamics of soft capsules is widely studied at low Reynolds numbers in canonical flows 41–45 and cellular blood flow simulations. 40įor biomedical applications of inertial microfluidics it is crucial to strive for a deeper understanding of the inertial migration of deformable capsules. Soft capsules experience an additional lift force induced by the deformability of the cell, which drives them towards the channel center and which thereby competes with the inertial lift force. Subsequently, Hur and co-workers 39 experimentally showed inertia-driven separation and enrichment of deformable capsules. 38 demonstrated ordering and separation of particles in a microchannel using inertial focussing, which gave rise to the field of inertial microfluidics. For almost five decades from the observation of the Segré–Silberberg effect, inertial migration was mainly a blue-skies-research problem. 36 Applying an external force to the solid particle along the channel axis, the resulting Saffman force 37 also contributes significantly to the force balance in the cross-stream direction. Inertial migration of a neutrally buoyant solid particle is essentially the result of a balance between shear-gradient lift force, directed towards the channel wall, 35 and a wall repulsion force, directed towards the channel center. Inertial focussing was first reported by Segré and Silberberg for solid particles with the well-known tubular pinch effect 21,22 and then spurred numerous theoretical, 23–26 computational, 19,27–30 and experimental 31–34 studies to gain a deeper understanding of this phenomenon. In this article, we investigate how different factors such as shape, softness, and position influence the motion of a pair of particles in a microfluidic channel. The possibility to attain high throughput makes inertial microfluidics an attractive option among other microfluidic particle-separation techniques. In contrast to common microfluidic lab-on-a-chip devices in which fluid inertia is negligible, inertial microfluidics operates in an intermediate range between Stokes and turbulent regimes, where flow is still laminar. 13 On the other hand, deterministic lateral displacements at low Reynolds number using appropriately placed pillars 14 and inertial microfluidics 15–20 exploit internal hydrodynamic forces to achieve particle separation. 9 Lab-on-a-chip techniques using external force fields include optical tweezers, 10 dielectrophoresis, 11 magnetophoresis, 12 and acoustophoresis. 8 Lab-on-a-chip devices for separating particles and biological cells rely on external force fields or internal hydrodynamic forces. In recent years, microfluidic 6 lab-on-a-chip devices 7 have emerged as a promising technique to precisely manipulate and control biological cells needed on a commercial level. 1 Introduction Biomedical studies of biological cells play a crucial role in diagnosing several fatal diseases 1 such as malaria, 2 cancer, 3,4 and the human immunodeficiency virus (HIV) infection, 5 to name a few. Furthermore, a pair with both capsules in the same channel half is more prone to become unstable than a pair with capsules in opposite channel halves. We show that stable pairs become unstable when increasing the particle stiffness. The observed two-particle motions in the present work can be categorized into four types: stable pair, stable pair with damped oscillations, stable pair with bounded oscillations, and unstable pair. We also change their deformability from relatively soft to rigid and choose spherical and biconcave particle shapes. We study the influence of different starting positions for mono- and bi-dispersed pairs. We perform three-dimensional lattice Boltzmann simulations combined with the immersed boundary method to unravel the dynamics of various mono- and bi-dispersed pairs in inertial microfluidics. ![]() This will help to develop an understanding of the dynamics of particle trains in inertial microfluidics, which are typical structures in multi-particle systems. ![]() The article focuses on the hydrodynamic interaction of two particles. Inertial microfluidics exploits internal hydrodynamic forces and the mechanical structure of particles to achieve separation and focusing. Lab-on-a-chip devices based on inertial microfluidics have emerged as a promising technique to manipulate particles in a precise way.
0 Comments
Leave a Reply. |
Details
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |